There are several different types of pancreatic neuroendocrine tumors (PNETs), which are classified based on their histology and hormone production. The following are the various types of PNETs.
- Insulinomas are PNETs that produce insulin, which can cause hypoglycemia and are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome.
- Gastrinomas are PNETs that produce gastrin, which can cause stomach ulcers and other gastrointestinal symptoms and are associated with Zollinger-Ellison syndrome.
- Glucagonomas are PNETs that produce glucagon, which can cause hyperglycemia and other symptoms and are associated with glucagonoma syndrome.
- Somatostatinomas are PNETs that produce somatostatin, which can cause diabetes and other symptoms and are associated with somatostatinoma syndrome.
- VIPomas are PNETs that produce vasoactive intestinal peptide (VIP), which can cause watery diarrhea, electrolyte imbalances, and other symptoms and are associated with VIPoma syndrome.
It’s important to note that not all PNETs are associated with specific genetic syndromes, and that some PNETs may produce multiple hormones or have a mixed histology.
More information at the American Cancer Society.